Credits: 3 3-0-0)
Prerequisites: Pre-requisite(s): EC 75 and SBL100 for UG students
Description
Introduction to endocytosis and intracellular trafficking – Structure, function and dynamics of Clathrin-mediated endocytosis; Clathrin- independent endocytosis; Receptor-mediated endocytosis; Traffic through endocytic and secretory pathway; Regulation of intracellular trafficking by vesicle fusion; Endosomal system and sorting; Biogensis of endosomes and lysosomes; Functions of Rab GTPases in vesicle fusions; Role of SNAREs in phagosome maturation; Modulation of phagosome maturation by intracellular pathogens: Mycobacterium;
Legionella; Salmonella etc.; Intracellular trafficking and antigen presentation; Human diseases due to defect in intracellular trafficking: Lysosomal storage disease, Atherosclerosis, Niemann Pick C Diseases, Cancers, Neurodegeneration; Exploiting and endocytosis for nanomedicine.
Prerequisite Tree
flowchart TD
SBL725-1536[SBL725]
SBL725-1536 --> EC75-1536[EC75]
SBL725-1536 --> SBL100-1536[SBL100]
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