Credits: 3 (3-0-0)
Prerequisites: EC 75 and SBL100/BBL131/CML101/ Equivalent
Description
Neural physiology overview; Elements of excitable cell membrane: ion channels, transporters and cytoskeletal elements; Physical principles of neuronal excitability: Diffusion, Electro-diffusion, Nernst-Plank Equation, Donnan equilibrium, Goldman-Hodgkin-Katz equation; Concept of Resting membrane potential (RMP), maintenance of RMP- Pumps and transporters; Exemplar pump: Na+-K+ ATPase-structure and function; Pores in the membrane: Ion channels; Hodgkin-Huxley model for Na+ and K+ channels; Action potentials; Ion channel structure, function & modulation; Synaptic transmission: vesicle transport and recycling, neurotransmitter release; Neurotransmitter- receptor structure-function; Methods to study ion channels and receptors: Patch-Clamp, planar-bilayer, crystallography and Cryo-EM studies; Action potential generation and conduction: Mechanism and models; Simulation of neural activity
Prerequisite Tree
flowchart TD
SBL723-1530[SBL723]
SBL723-1530 --> EC75-1530[EC75]
SBL723-1530 --- Or1531[Any one of]:::empty
Or1531 -.-> SBL100-1532[SBL100]
Or1531 -.-> BBL131-1533[BBL131]
Or1531 -.-> CML101-1534[CML101]
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